LMWH is primarily metabolized in which organ?

LMWH is primarily metabolized in which organ?

• A. In the kidney
• B. In the liver
• C. In the spleen
• D. In the plasma

Answer: (A)

LMWH is cleared from the body primarily by the kidneys. It is eliminated mainly through renal excretion (glomerular filtration) with minimal hepatic metabolism. Because the liver is not the main route of elimination, hepatic disease does not drive LMWH clearance, and the spleen or plasma pathways are not the primary routes either. This renal predominance is why dosing often needs adjustment in patients with kidney impairment, and why accumulation can occur if renal function is poor.

LMWH is cleared from the body primarily by the kidneys. It is eliminated mainly through renal excretion (glomerular filtration) with minimal hepatic metabolism. Because the liver is not the main route of elimination, hepatic disease does not drive LMWH clearance, and the spleen or plasma pathways are not the primary routes either. This renal predominance is why dosing often needs adjustment in patients with kidney impairment, and why accumulation can occur if renal function is poor.