Rheumatoid factor targets which immunoglobulin?

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Multiple Choice

Rheumatoid factor targets which immunoglobulin?

Explanation:
The idea here is that rheumatoid factor is an autoantibody directed against another immunoglobulin. It specifically targets the Fc portion of IgG. So the immunoglobulin that RF binds to is IgG. In practice, the RF that’s commonly detected is an IgM autoantibody against IgG Fc, forming immune complexes that can drive inflammation in rheumatoid arthritis. The other immunoglobulins listed are not the typical targets of RF.

The idea here is that rheumatoid factor is an autoantibody directed against another immunoglobulin. It specifically targets the Fc portion of IgG. So the immunoglobulin that RF binds to is IgG. In practice, the RF that’s commonly detected is an IgM autoantibody against IgG Fc, forming immune complexes that can drive inflammation in rheumatoid arthritis. The other immunoglobulins listed are not the typical targets of RF.

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